Illustration: Qualia NAD+ with three NAD+ precursors, resveratrol and B-complex.
★★★★★
4.6 / 5 based on Amazon customer reviews
£62.00 on Amazon
Qualia NAD+ combines three NAD+ precursors — nicotinamide riboside (NIAGEN®), niacin and niacinamide — with trans-resveratrol, a B-vitamin complex, marine magnesium from Aquamin®, and a small amount of caffeine from Coffeeberry®. One bottle provides a 30-day supply at two capsules per day.
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- Key ingredients: NIAGEN® nicotinamide riboside (300mg), niacin, niacinamide, trans-resveratrol, B-complex, Aquamin® marine magnesium, Organic Coffeeberry® (28mg caffeine)
- Serving: 2 capsules daily, morning, with or without food
- Supply: 60 capsules (30 days)
- Clinical claim: 67% average increase in whole-blood NAD+ after 28 days in company-sponsored placebo-controlled trial (preprint/under peer Overview)
- Dietary: Vegan, non-GMO, gluten-free
- Subscribe Save: £55.80 on Amazon
- Seller: Amazon (Qualia Life Sciences)
What Is Qualia NAD+?
Qualia NAD+ is a premium, multi-pathway NAD+ support supplement from Neurohacker Collective / Qualia Life Sciences. Rather than relying on a single precursor (as most NR or NMN and NAD+ precursors products do), it supplies three different forms of vitamin B3 — nicotinamide riboside, niacin and niacinamide — plus cofactors intended to support the enzymes that convert those precursors into NAD+. These include trans-resveratrol, B-complex vitamins and marine magnesium (Aquamin®), plus a small amount of caffeine from Coffeeberry® to support NMNAT2 enzyme activity.
The formula is built on the premise that NAD+ is made through multiple cellular pathways (the salvage pathway, the Preiss-Handler pathway) and that supporting several pathways at once may outperform a single precursor alone. The company has sponsored two placebo-controlled human trials and published a preprint reporting a 67% average increase in whole-blood NAD+ after 28 days.
🐢 Tortoise Wisdom
"Three precursors and a stack of cofactors sounds sophisticated — and it is. But sophisticated does not always mean better value. Compare the price per day and the independence of the evidence before buying."
Product Overview
We are reviewing Qualia NAD+ because it is one of the few NAD+ products on Amazon that combines a clinically studied precursor dose (300mg NIAGEN®) with additional B3 forms and absorption/metabolism cofactors. It is also one of the few brands to have conducted and published its own randomised, double-blind, placebo-controlled trial — even if that trial is company-sponsored and currently under peer Overview.
✅ Pros
- 300mg NIAGEN® nicotinamide riboside per serving (dose used in several published NR trials)
- Three NAD+ precursors for multi-pathway support
- Includes resveratrol, B-complex and marine magnesium as NAD+ metabolism cofactors
- Company-sponsored placebo-controlled human trial published as preprint; under peer Overview
- Vegan, non-GMO, gluten-free, transparency-verified by Amazon
⚠️ Considerations
- £62 for a one-month supply is expensive compared with standalone NR, NMN or niacinamide products.
- Clinical evidence is company-sponsored; independent replication is lacking.
- 28mg caffeine may be unwanted for caffeine-sensitive users or those taking it late in the day.
- Niacin content may cause mild flushing in sensitive individuals; check the label.
- NMN cannot be lawfully marketed as a supplement in some jurisdictions; Qualia uses NR instead, which is a safer regulatory choice but not identical to NMN.
What the Research Says
The NAD+ precursor field is evolving rapidly. The strongest human evidence currently exists for nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), with dozens of placebo-controlled trials showing moderate increases in NAD+ levels and some improvements in blood pressure, muscle function and metabolic markers. However, no human trial has shown that raising NAD+ extends lifespan.
Qualia's own study (Blomquist et al., 2025, medRxiv preprint) reported a statistically significant increase in whole-blood NAD+ after 28 days compared with placebo, and male participants showed improvements in the Aging Males Symptoms scale. The study was small (49 enrolled, 25 with complete NAD+ data), company-sponsored, and not yet independently replicated. We rate it as promising but preliminary.
Blomquist et al., 2025 — medRxiv (Qualia-sponsored)
Randomised, double-blind, placebo-controlled trial of Qualia NAD+ reporting increased whole-blood NAD+ after 28 days. Preprint, under peer Overview.
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Conze et al., 2019 — Scientific Reports (NIAGEN®)
NR 300mg/day raised whole-blood NAD+ by an average of 48% over 8 weeks in healthy overweight adults.
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Martens et al., 2018 — Nature Communications (NR)
NR 500mg twice daily modestly lowered systolic blood pressure in middle-aged and older adults with elevated BMI.
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Liao et al., 2021 — Frontiers in Cell and Developmental Biology (NMN)
NMN 300mg/day improved walking endurance and sleep quality in older adults in a small placebo-controlled trial.
View DOI
Read our broader guides on NMN and NAD+ precursors and NR vs NMN comparison.
Comparison: Qualia NAD+ vs Single-Ingredient NAD+ Boosters
| Feature | Details |
|---|
| Feature | Qualia NAD+ Qualia NAD+: Single NR product Single NR product: Single NMN product |
| Precursors | NR + niacin + niacinamide Qualia NAD+: NR only Single NR product: NMN only |
| NR dose | 300mg NIAGEN® Qualia NAD+: 300–500mg Single NR product: N/A |
| Cofactors | Resveratrol, B-complex, Mg, caffeine Qualia NAD+: Usually none Single NR product: Usually none |
| Cost per month | £55.80–£62.00 Qualia NAD+: £25–£50 Single NR product: £30–£70 (variable) |
| Trial quality | Company-sponsored preprint/peer-Overview Qualia NAD+: Several independent trials Single NR product: Growing independent trial base |
| Format notes | Buyers wanting a researched "all-in-one" NAD+ stack Qualia NAD+: Cost-conscious NAD+ support Single NR product: Buyers specifically seeking NMN |
Qualia NAD+ is the premium, research-backed stack option. Single NR or NMN products are usually cheaper but lack the multi-pathway and cofactor design.
Summary
Qualia NAD+ is one of the more sophisticated NAD+ supplements available on Amazon. It uses a clinically relevant 300mg dose of NIAGEN®, adds two additional B3 precursors, and supports NAD+ metabolism with resveratrol, B-vitamins and magnesium. The 67% NAD+ claim is based on a company-sponsored trial that is currently under peer Overview, so treat it as promising rather than definitive. At £55–£62 per month, it is a premium purchase most appropriate to buyers who value an all-in-one, research-oriented stack over the lowest price per milligram.
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