Alpha-Ketoglutarate (AKG) Supplements UK 2026: Buying Guide

Ca-AKG vs plain AKG, dose and what the mouse lifespan data mean.

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TL;DR: Calcium alpha-ketoglutarate (Ca-AKG) is the form used in most longevity research. Plain AKG is more common in sports supplements but has less lifespan data. Typical longevity doses are ~1 g/day of Ca-AKG. Read our full Ca-AKG evidence review.

🐢 Tortoise Wisdom"For longevity, Ca-AKG is the form with the mouse data. Plain AKG is a different product."

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1. What Is AKG?

Alpha-ketoglutarate is a Krebs-cycle metabolite involved in energy production, epigenetic regulation and collagen synthesis. Calcium AKG is a buffered, better-absorbed form.

2. Ca-AKG vs AKG

  • Ca-AKG: used in lifespan studies; provides calcium plus AKG; usually 500 mg–1 g/day.
  • Plain AKG: common in sports products; less longevity-specific evidence.

3. Buying Checklist

  • Form: look for 'calcium alpha-ketoglutarate' or 'Ca-AKG'.
  • Amount: compare per serving; some labels are confusing about elemental vs total weight.
  • Purity/COA: standard.

4. Safety

Short-term safety is good. Long-term human data are limited. AKG may lower blood pressure and blood sugar; people on related medications should consult a clinician.