Qualia NAD+ Review 2026: Does the 67% NAD+ Claim Stack Up?

Qualia NAD+ is a sophisticated, multi-pathway NAD+ booster built around 300mg of NIAGEN® nicotinamide riboside, plus niacin, niacinamide, trans-resveratrol evidence, B-complex vitamins and marine magnesium glycinate guide. A company-sponsored placebo-controlled trial (currently under peer review) reported a 67% average increase in whole-blood NAD+ after 28 days. That is promising but not yet independently replicated. At £55.80–£62/month, Qualia NAD+ is a premium choice best suited to buyers who want a researched, all-in-one stack rather than the cheapest per-milligram NAD+ option.

1. What Is Qualia NAD+?

Qualia NAD+ is made by Qualia Life Sciences, the company behind the well-known nootropic stack Qualia Mind. Unlike standalone NR or NMN products, Qualia NAD+ aims to support NAD+ production through multiple pathways and with multiple cofactors. Its key ingredients include:

• NIAGEN® nicotinamide riboside chloride (300mg): The most clinically studied patented form of NR.
• Niacin (nicotinic acid): The original flushing form of vitamin B3, converted via the Preiss-Handler pathway.
• Niacinamide (nicotinamide): The non-flushing form of B3, recycled via the salvage pathway.
• Trans-resveratrol: Polyphenol linked to sirtuin activity and mitochondrial stress response.
• B-complex vitamins: Cofactors for mitochondrial energy metabolism.
• Aquamin® marine magnesium: Bioavailable magnesium source supporting ATP production.
• Organic Coffeeberry® (28mg caffeine): Whole coffee fruit extract included to support NMNAT2 enzyme activity, particularly in neurons.

The pitch is that NAD+ is so important to cells that evolution gave us several ways to make it. Qualia tries to support three of those ways simultaneously, while also supplying the enzymatic and mineral cofactors needed to turn precursors into NAD+.

2. The 67% NAD+ Claim: What the Trial Actually Shows

Qualia's headline claim comes from a randomised, double-blind, placebo-controlled trial registered and run between October 2023 and March 2024. Key facts:

• Participants: 92 adults recruited; 49 completed baseline NAD+ measurement; 25 had both baseline and final NAD+ measurements.
• Duration: 28 days.
• Dose: Two Qualia NAD+ capsules daily.
• Primary endpoint: Change in whole-blood NAD+ measured by at-home finger-prick kits.
• Result: Statistically significant average increase in whole-blood NAD+ versus placebo.
• Secondary finding: Males showed improvements in overall and somatic Aging Males Symptoms scores, though the study notes limited statistical power.

The trial is currently under peer review and available as a preprint on medRxiv (Blomquist et al., 2025). Company-sponsored research is not automatically invalid, but it carries a higher risk of bias than independent trials. We classify this result as promising preliminary evidence, not definitive proof of superiority over cheaper NR or NMN products.

3. Ingredient Breakdown and Evidence

NIAGEN® Nicotinamide Riboside (300mg)

This is the same dose used in Conze et al. (2019), where NR raised whole-blood NAD+ by an average of 48% over 8 weeks in healthy overweight adults. NIAGEN® is the most-studied patented NR form and is generally well tolerated.

Niacin and Niacinamide

Both are established vitamin B3 forms that feed into NAD+ synthesis. Including them alongside NR provides theoretical redundancy, but also increases total B3 load. The niacin dose is kept below the typical flushing threshold, though sensitive individuals may still notice warmth or tingling.

Trans-Resveratrol, B-Complex and Magnesium

These are sensible cofactors. Resveratrol has a mixed but active research base around sirtuins and cardiovascular health. B-vitamins are essential for mitochondrial function. Magnesium is one of the most common dietary deficiencies locally and supports ATP metabolism. The amounts here are supportive rather than therapeutic.

Organic Coffeeberry® and Caffeine

The 28mg caffeine is roughly a third of a small coffee. Qualia cites in-vitro research suggesting caffeine may support NMNAT2, an enzyme involved in NAD+ synthesis in neurons. This is an interesting mechanistic angle, though human relevance is unclear at this dose.

4. Product Review: Qualia NAD+

What You Get

• 60 capsules per bottle — a 30-day supply at two capsules per day.
• 300mg NIAGEN® plus niacin, niacinamide and resveratrol.
• Vegan, non-GMO, gluten-free, transparency-verified by Amazon.
• Sold on Amazon at £62.00 one-time or £55.80 Subscribe Save.

What to Consider

• High monthly cost compared with plain NR or NMN.
• Company-sponsored evidence, not yet peer-reviewed at time of writing.
• Contains caffeine; avoid late-day dosing if sensitive.
• Niacin may cause mild flushing in some users.

5. How Qualia NAD+ Compares to Other NAD+ Boosters

Qualia NAD+ sits at the premium end of the NAD+ market. If you want the simplest, cheapest NAD+ boost, plain NR or NMN is likely better value. If you want a formulated stack with a company-sponsored trial behind it, Qualia is the more polished option.

6. Safety and Interactions

Because Qualia NAD+ contains multiple B3 forms, total niacin-equivalent intake matters. High-dose B3 can cause flushing, gastrointestinal upset and, at very high doses over long periods, liver enzyme elevations. It can also interact with blood-pressure medication, diabetes drugs and statins. The resveratrol and caffeine add further interaction potential. People with liver disease, gout, hypotension, or those on multiple medications should speak to a clinician before using this product.

7. References

8. FAQ